Teduglutide
ALSO KNOWN AS · Gattex · Revestive
A GLP-2 analogue approved for short bowel syndrome. It is not a weight-loss drug — GLP-2 acts on intestinal growth and absorption, not appetite.
Mechanism
GLP-2 is cleaved from the same proglucagon precursor as GLP-1 but signals through its own receptor on subepithelial myofibroblasts and enteric neurons. Activation increases villus height, crypt depth and mucosal blood flow, improving absorptive capacity.
Teduglutide substitutes alanine with glycine at position 2 to resist DPP-4, extending the half-life from minutes to hours.
PRIMARY SOURCES
- 01Teduglutide in short bowel syndrome— Gastroenterology
Educational reference only. Trial figures are protocol-condition means, not individual predictions. Investigational compounds are not approved medicines and have no legitimate consumer supply route.