The GLP wiki
Start here if the names are the confusing part. These pages explain GIP and the GLP hormones — where they come from, which receptors they hit, and which popular terms refer to nothing at all.
What is GLP-1? Mechanism, receptors and the clinical landscape
GLP-1 is a gut-derived hormone that shaped an entire drug class. Here is what it actually does in the body, and what separates real biology from marketing language.
11 MIN READ · 7 SOURCES
/WIKI/GIPGIP: the other incretin hormone
GIP is secreted from intestinal K-cells after nutrient intake and acts on its own receptor — distinct from GLP-1. For years it looked like a dead end as a medicine; dual and triple agonists revived it as a partner target. Here is the physiology, the history, and what human trials actually show.
11 MIN READ · 8 SOURCES
/WIKI/AMYLINAmylin: the beta-cell partner hormone
Amylin is a 37-amino-acid hormone packed with insulin in beta-cell secretory granules and released after meals. It slows gastric emptying, suppresses postprandial glucagon, and signals satiety through pathways that are distinct from the incretins. Here is the physiology, the approved analogue, and what investigational long-acting agonists are trying to do.
12 MIN READ · 6 SOURCES
/WIKI/GLUCAGON-RECEPTOR-AGONISMGlucagon receptor agonism in metabolic peptides
Native glucagon raises blood glucose mainly through hepatic pathways and acts on the glucagon receptor (GCGR). Engineered dual and triple agonists deliberately include controlled GCGR activity for metabolic and energy-expenditure effects — but that pharmacology is not the same as an approved ‘glucagon obesity drug.’ This page separates physiology, multi-agonist design, and investigational status.
12 MIN READ · 8 SOURCES
/WIKI/GLP-2GLP-2: the intestinal sibling of GLP-1
Cleaved from the same proglucagon precursor as GLP-1, GLP-2 acts on an entirely different receptor and does an entirely different job: it grows, repairs and increases the absorptive capacity of the intestinal lining.
9 MIN READ · 5 SOURCES
/WIKI/GLP-3What people mean by "GLP-3": retatrutide and triple agonists
"GLP-3" is not a real hormone name in endocrinology textbooks — it is shorthand people use for triple-receptor agonist peptides. Here is what that means and what is actually known.
10 MIN READ · 6 SOURCES
Looking for a specific compound?
The concept pages cover the hormones. Individual molecules — 35 of them, from semaglutide to BPC-157 — live in the compound library, each with class, receptor targets, route, half-life, evidence summary and primary sources.
EDUCATIONAL REFERENCE ONLY · Not medical advice. Nothing here diagnoses, treats, cures or prevents any disease, and nothing here is a dosing recommendation. Consult a licensed clinician before any treatment decision.