MOTS-c
ALSO KNOWN AS · Mitochondrial ORF of the 12S rRNA type-c
A mitochondria-encoded peptide that acts as a metabolic regulator, activating AMPK and improving insulin sensitivity and exercise capacity in mice. Human data are observational rather than interventional.
Mechanism
MOTS-c influences folate-methionine metabolism and translocates to the nucleus during metabolic stress, regulating adaptive gene programmes. In mice it prevents diet-induced obesity and insulin resistance.
Human data
Circulating MOTS-c levels correlate with metabolic health and exercise adaptation, but no randomised human dosing trial has reported efficacy.
PRIMARY SOURCES
- 01MOTS-c regulates metabolic homeostasis— Cell Metabolism
Educational reference only. Trial figures are protocol-condition means, not individual predictions. Investigational compounds are not approved medicines and have no legitimate consumer supply route.