TB-500
ALSO KNOWN AS · Thymosin beta-4 fragment · Tβ4
A synthetic fragment of thymosin beta-4, an actin-sequestering peptide involved in cell migration and wound repair. Full-length Tβ4 has been through human trials for dry eye and corneal wounds; the TB-500 fragment sold for research has no approved human indication.
Mechanism
Thymosin beta-4 binds G-actin and regulates cytoskeletal assembly, supporting keratinocyte and endothelial migration. This underpins its studied roles in corneal repair, dermal wound closure and cardiac remodelling after ischaemia.
Regulatory status
Tβ4 eye drops reached late-stage trials for neurotrophic keratopathy. Injectable TB-500 is banned in sport by WADA and is not approved for human therapeutic use.
PRIMARY SOURCES
- 01Thymosin beta-4 in tissue repair— Annals of the New York Academy of Sciences
- 02WADA Prohibited List— World Anti-Doping Agency
Educational reference only. Trial figures are protocol-condition means, not individual predictions. Investigational compounds are not approved medicines and have no legitimate consumer supply route.