Exenatide
ALSO KNOWN AS · Byetta · Bydureon · Exendin-4
The first GLP-1 receptor agonist to reach market, a synthetic version of exendin-4 originally isolated from Gila monster venom.
Origins
Exendin-4 occurs naturally in the salivary secretions of the Gila monster and shares roughly 53% sequence identity with human GLP-1 while being naturally resistant to DPP-4. It launched the entire therapeutic class in 2005.
PRIMARY SOURCES
- 01Exenatide clinical pharmacology— Diabetes Care
Educational reference only. Trial figures are protocol-condition means, not individual predictions. Investigational compounds are not approved medicines and have no legitimate consumer supply route.